![]() (The FDA also notes that there is no safety data on treating more than eight migraines in a 30-day period with this medication.) However, it’s not recommended that you take more than one spray in a 24-hour time period. The recommended dose is 10 milligrams given as a single spray in one nostril as needed, according to the FDA. Zavzpret is known as a small molecule CGRP receptor antagonist, and it’s designed to be used as an alternative to other migraine treatments, including triptans, which are a different class of drugs used to treat migraine pain, Pfizer says. While it’s not the first nasal spray for migraine, it uses a new approach with a treatment that tries to block the release of proteins called calcitonin gene-related peptides, which increase during a migraine attack, leading to inflammation and pain. Zavzpret is a nasal spray that’s designed to help stop migraine pain. Here’s what you need to know about Zavzpret, plus how it works. ![]() But it’s understandable to have questions, given that the medication helped just 24% of those dealing with migraine pain. ![]() Having as many tools as possible to provide acute relief and to improve quality of life is imperative.”Īngela Hwang, chief commercial officer and president of Global Biopharmaceuticals Business for Pfizer called the medication a “significant breakthrough for people with migraine who need freedom from pain and prefer alternative options to oral medications” in a press release. “Additionally, migraine continues to affect more than 1 billion people worldwide (one in five women, and one in 16 men), and is the second leading cause of disability worldwide. “In many patients, traditional acute treatment options for migraine, including triptans, are either ineffective or contraindicated,” says Brittany Mays, M.D., assistant professor of neurology at the Vanderbilt University School of Medicine. The researchers found that about 24% of those who took Zavzpret had no pain after 30 minutes to two hours, while 15% of those who took the placebo reported the same results. The study followed 1,269 patients with migraine headaches-half were given Zavzpret and half were given a placebo when they had a migraine. The medication isn’t perfect, but clinical trial results posted in the journal Lancet Neurologyshow that the drug performed better than a placebo at providing migraine headache relief. Zavzpret (zavegepant) is a nasal spray that can help provide pain relief in as little as 15 minutes in adults with migraines. The Food and Drug Administration has approved a new medication to treat migraine headaches.
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